The structures 尽管…但是… and 尽管…可是… are used in the same way. They mean “although..., but...” or “even though...”.
In a sentence, the first clause beginning with 尽管 expresses background information, while the second clause beginning with 可是 or 但是 expresses the fact or conclusion you assert.
Examples
尽管这次考试很难,但是很多人都通过了
Despite the difficulty of this exam, many people passed